Determination of Plasma Tenofovir Concentrations Using a Conventional LC-MS Method
نویسندگان
چکیده
منابع مشابه
A conventional LC-MS method developed for the determination of plasma raltegravir concentrations.
Raltegravir belongs to a new class of antiretrovirals acting for a human immunodeficiency virus (HIV)-1 integrase inhibition. Clinical trials of this drug have demonstrated potent antiviral activity in both therapy naïve and experienced patients. Thus, raltegravir has become an important component of combination treatment regimens used to treat patients with multidrug-resistant HIV-1. The quant...
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A simple, specific, sensitive LC/MS/MS method for the quantitation of tenofovir (TFV) in monkey plasma was developed and validated. After the addition of adefovir as an internal standard (IS), methanol was used to produce a protein-free extract. Isocratic chromatographic separation was performed on a reverse-phase Discovery C(18) column (4.6×250 mm, 5 µm). The mobile phase consisted of methanol...
متن کاملValidation of a selective method for determination of paroxetine in human plasma by LC-MS/MS.
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ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 2007
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.30.1784